The probablility of an HD patient developing thrombosis by 60 years of age can be as high as 80%
HD is associated with a significant risk of venous thrombosis in high-risk situations
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Welcome to ATIII.com, Your Resource for
Information on Hereditary Antithrombin Deficiency
We are pleased to bring you this HD Web Site. Our mission is to inform patients and physicians about our current clinical trial, to provide a forum for sharing information, and to enhance the health and lives of families affected by this
coagulation disorder.
Antithrombin is an important anticoagulant in human serum. It regulates
thrombin, a blood protein that plays a key role in controlling clot formation. Patients with Hereditary Antithrombin Deficiency, or HD, can have either
Type I or Type II deficiency. Type I is a quantitative deficiency characterized
by low levels of antithrombin. Type II is a qualitative deficiency characterized
by the presence of antithrombin variants which do not function properly. A
survey of the literature suggests that Type I HD patients are generally more
prone to venous thromboembolism than Type II patients.
Individuals with Hereditary Antithrombin Deficiency are at risk for blood
clots, organ damage or even death. Sometimes the clots can form
spontaneously, putting an individual at sudden and unexpected risk. Other
research suggests that HD may contribute to fetal loss. HD patients are
perhaps at greatest risk during events which are independently associated
with a probability of thrombosis, such as surgery and delivery.
We invite you to browse through the site, learn about new developments
in the field, hear from patients and physicians, and post your own questions and comments.
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HAVE YOU BEEN DIAGNOSED?
Learn about GTC's current trial using recombinant human antithrombin.
Learn more.
WHAT IS RECOMBINANT ANTITHROMBIN?
Recombinant Human Antithrombin, rhAT, is a new investigational agent and a potential therapeutic option for patients with HD.
Learn more.
 
The National Alliance for Thrombosis and Thrombophilia (NATT)
Antithrombin Deficiency Brochure
Click Here to download
Read Taylor's Story
An HD patient discusses learning about,
and living
with hereditary antithrombin deficiency.
Read it now
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